By Ramana S. Moorthy, MD
A dialogue of the scientific method of uveitis ends up in commonly rewritten chapters on noninfectious (autoimmune) and infectious kinds of uveitis. additionally lined are endophthalmitis, masquerade syndromes, and issues of uveitis. A dialogue on ocular involvement in AIDS has been up to date. The part on immunology describes the human immune reaction in phrases that make it hugely obtainable to readers.
Read or Download 2008-2009 Basic and Clinical Science Course: Section 9: Intraocular Inflammation and Uveitis (Basic and Clinical Science Course 2008-2009) PDF
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Extra info for 2008-2009 Basic and Clinical Science Course: Section 9: Intraocular Inflammation and Uveitis (Basic and Clinical Science Course 2008-2009)
Such transplantations require the recipient to produce afferent, processing, and effector responses to the transplant, all modified by the unique location. Chapter 3 describes regional immune concepts relevant to the eye. See also BCSC Section 8, External Disease and Cornea, for a discussion of the regional immunity of the cornea in Part XI, Corneal Transplantation. 28 . Intraocular Inflammation and Uveitis Immunologic Microenvironments Regional immunologic differences occur because different tissue sites are composed of different immunologic microenvironments.
4, With the help of costimulatory molecules such as C028/87 interaction and cytokines, the C08 T lymphocyte becomes primed, or partially activated. A similar mechanism is used to recognize tumor antigens that are produced by cells after malignant transformation. (Illustration by Barb Cousins, modified by Joyce Zavarro.! 22 . Intraocular Inflammation and Uveitis from another individual if the class I MHC molecules do not correspond. In general, class I APCs are best for processing peptide antigens that have been synthesized by the host cell itself, including most tumor peptides or viral peptides after host cell invasion.
Eosinophils and neutrophils appear to be absent. Under various clinical or experimental conditions, however, high densities of T lymphocytes, B lymphocytes, macrophages, and neutrophils can infiltrate the choroid, choriocapillaris, and retina. The RPE and various cell types within the retina and the choroid (eg, pericytes) can synthesize many different cytokines (eg, TGF-~) that may alter the subsequent immune response. Local immune processing does not appear to occur. See also BCSC Section 12, Retina and Vitreous.